A
Aspect Tiling
I would look at putting a centre line form the middle of the door to the opposite wall. This way you would have a grout line running from the middle of the door to the opposite wall or a full tile centered on the door running to the wall. Looks better this way IMO because you'll be drawn to it every time you enter the room. As Joe said, you should also consider using other features such as the fireplace to center your tiles. Personal preferance really. Don't rush the setting out process, try a couple of options and see what looks best.
Pete
Pete