Re reading the facts as printed it would seem as though the tiles have not stuck to the plywood. It could be due to the pva adhesive,the adhesive type, dust on floor/back of
tile and certainly the dot and dab method of fixing. If it is only 18mm plywood fixed direct to the joists and tiled direct to this - as previously stated - a deflection issue may be the cause. Is there any cracks appearing at 120cm widths or just loose tiles and is the grout cracking out of the joints?
My earlier post was just concerned that the weight of the new kitchen/worktops had increased the movement in the floor and has the area of supported wall removal been adequately reinforced to hold the central island.
Following Daves advice I would certainly request a site visit by an experienced tiling contractor and he /she may be able to confirm some of the issues you may face.
Your builder -the main contractor- is the person with the answers so I'd ask him if he is a member of a Building Federation so you may be able to ask their advice:smilewinkgrin: